Our Technology
Welcome to our unique medical diagnostic platform, where cutting-edge molecular detection technology meets innovation. Utilizing gold nanoparticles, photonic crystals, and advanced microscopic imaging, our system offers a superior level of detection compared to traditional PCR methods, requiring little to no enzymatic amplification. Designed for liquid biopsies, our platform efficiently analyzes blood, plasma, sputum, urine, and semen, enabling complete detection of DNA, RNA, and proteins. Experience the future of diagnostics with unparalleled accuracy and convenience.
This technology is in development and is not FDA approved. Performance claims have not been reviewed by the FDA.
Instrument
PRAM (Photonic Resonance Absorption Microscopy) provides recorded images allowing for both qualitative and quantitative results. PRAM combines the speed, simplicity, and affordability of a Point-of-Care device with the quality and accuracy of a core lab.
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Multiplex capabilities
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Qualitative and quantitative results
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Sensitivity is better than PCR
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Portable design
Assays
The instrument runs three different assay formats depending on the analyte to be detected. AC + DC, TRAP and AC3 all can be handled on a cartridge.
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SNV Detection
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Minimal sample prep for a range of sample types
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No enzymatic amplification on 2 of 3 formats
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Sample to results in less than 30 minutes
Collaborations
Mayo Clinic working on lung cancer test
Huntsman Cancer Center working on prostate cancer test
Mount Sinai working on liver cancer test
Stanford working on sample preparation
Publications
Over 100 Publications have been generated from the research work . For a list of the most recent ones, please contact us.
In this paper, we describe a biosensing instrument based on our previously developed photonic resonator absorption microscope (PRAM) that incorporates autofocus, digital representation of the gold nanoparticle (AuNP) accumulation, and the ability to gather time-series image sequences of AuNP attachment and detachment from the photonic crystal (PC) surface. The combined capabilities are used to fully automate PRAM image collection during biomolecular assays to enable tiling of PRAM images to provide millimeter-scale field of view. The instrument can also gather PRAM “movies” that enables digital showcasing and dynamic counting AuNPs as they arrive and depart from the PC surface. We utilize the capabilities in the context of two biomolecular assays for detection of protein biomarkers in a conventional AuNP-tagged sandwich format. Utilizing dynamic counting of AuNP attachment and detachment events during the assay we present a detection for microRNA-375 (miRNA-375) down to 1 aM with a 10-min, room temperature, enzyme-free approach, while revealing characteristics of the binding-rate and unbinding-rate of the biomolecular interactions. Our instrument can potentially find broad applications in multiplexed point-of-care diagnostic testing, and as a general-purpose tool for quantitative characterization of biomolecular binding kinetics with single-molecule resolution.
